Wednesday, June 29, 2011

Lithium Prevents Parkinson's Brain Damage




It appears that for all neurological issues derived from progressive physical damage to the brain (which is likely just about everything) that lithium therapy is indicated as beneficial.

It certainly has been beneficial for bi polar disease and in fact has managed the disease entirely.   Been able to suddenly manage Alzheimer’s and Parkinson’s is a huge breakthrough.  The tests have started with Parkinson’s but they will certainly be tested everywhere else pretty quickly.

In the meantime patients are presently self medicating at known safe levels.  This means you can use it. And in fairness, these diseases are so horrible and naturally progressive that waiting to see if it actually works is pointless, so long as you will not die from the lithium.  You are certain to die from the diseases themselves, thus holding back is contra indicated.

Lithium Profoundly Prevents Brain Damage Associated with Parkinson's

Released: 6/20/2011 8:00 AM EDT 

Newswise — Lithium profoundly prevents the aggregation of toxic proteins and cell loss associated with Parkinson’s disease (PD) in a mouse model of the condition. Preclinical research is now underway at the Buck Institute for Research on Aging to determine correct dosages for a drug that continues to be the gold standard for the treatment of bipolar disorder. The Buck is currently working toward initiating a Phase IIa clinical studies of lithium in humans in conjunction with standard PD drug therapy. The research appears in the June 24 online edition of the Journal of Neuroscience Research.

“This is the first time lithium has been tested in an animal model of PD,” said lead author and Buck Professor Julie Andersen, PhD. “The fact that lithium’s safety profile in humans is well understood greatly reduces trial risk and lowers a significant hurdle to getting it into the clinic.”

According to Andersen, lithium has recently been suggested to be neuroprotective in relation to several neurodegenerative conditions including Alzheimer’s disease, Huntington’s disease and amyotrophic lateral sclerosis and has been touted for its anti-aging properties in simple animals. “We fed our mice levels of lithium that were at the low end of the therapeutic range,” said Andersen. “The possibility that lithium could be effective in PD patients at subclinical levels is exciting, because it would avoid many side effects associated at the higher dose range.” Overuse of lithium has been linked to hyperthyroidism and kidney toxicity.

PD is a progressive, incurable neurodegenerative disorder that affects 1 million Americans and results in tremor, slowness of movement and rigidity. It is the second most common neurodegenerative disease after Alzheimer’s. Between 50,000 and 60,000 new cases are diagnosed each year. Age is the largest risk factor for the PD. Onset usually begins between the ages of 45 and 70 years.

Andersen’s research focuses on lithium as a potential treatment for PD as well as its efficacy in combination with drugs currently used to control the symptoms of the disease. An internet search reveals stories from PD patients who are using lithium “off label” as part of their treatment regime; others report benefits from low dose lithium salts which are available as a supplement in some health food stores. “This finding gives us an opportunity to explore lithium as a recognized therapeutic for PD, in doses that are safe and effective” said Andersen.

Contributors to the work:

Other Buck Institute researchers involved in the study include Yong-Hwan Kim, Anand Rane and Stephanie Lussier. The research was supported by a grant from the National Institutes of Health.

Citation:

Lithium protects against oxidative stress-mediated cell death in alpha-synuclein over-expressing in vitro and in vivo models of Parkinson’s disease. JNR: 852471-744204

About the Buck Institute for Research on Aging:

The Buck Institute is the first freestanding institute in the United States that is devoted solely to basic research on aging and age-associated disease. The Institute is an independent nonprofit organization dedicated to extending the healthspan, the healthy years of each individual’s life. Buck Institute scientists work in an innovative, interdisciplinary setting to understand the mechanisms of aging and to discover new ways of detecting, preventing and treating conditions such as Alzheimer’s and Parkinson’s disease, cancer, cardiovascular disease and stroke. Collaborative research at the Institute is supported by new developments in genomics, proteomics and bioinformatics technology. For more information: www.thebuck.org.

1 comment:

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